GW-501516 10 MG per ML 30ML
$90.00
GW-501516 is 10 MG per ML. 30 ML
GW-501516 10 MG per ML 30ML
GW-501519 is a selective agonist (activator) of the PPARo receptor. (Peroxisome proliferator-activated receptor delta.) It display high affinity (k =1nM) and potency (EC50 = 1 nM) for PPARo with > 1000 fold selectivity over PPARo and PPARy.
In rats, binding of GW501516 to PPARδ recruits th coactivator PGC-1a. The PPARδ/coactivator complex in turn upregulates the expression of proteins involved in energy expenditure.
Furthermore, in rats treated with GW501516, potentially increased fatty acid metabolism in skeletal muscle, and potential protection against diet-induced obesity and type II diabetes was observed.
In obese rhesus monkeys, GW501516 may have helped increased high density lipoprotein (HDL) and lowered very low density lipoprotein (VLDL)
